In a large mixing bowl, combine the flaked salmon, breadcrumbs, beaten egg, chopped onion, parsley, garlic powder, onion powder, salt, pepper, paprika, Dijon mustard, mayonnaise, and lemon juice. Stir until everything is well incorporated. If the mixture feels too wet, add a little more breadcrumbs; if it feels too dry, add a bit more mayonnaise.
Using your hands, form the mixture into small patties about 2-3 inches in diameter. You should get approximately 8 patties from this mixture. Place them on a plate and let them sit for 5-10 minutes to firm up before cooking.
Heat olive oil in a large skillet over medium heat until hot but not smoking. Carefully place the patties in the pan without overcrowding them; cook for 3-4 minutes on each side until they are golden brown and crispy on the outside.
In a small bowl, whisk together Greek yogurt (or mayonnaise), lemon juice, lemon zest, minced garlic, honey (if using), Dijon mustard, salt, and pepper until smooth and creamy. Taste and adjust seasoning as necessary to suit your preference.
Drizzle or serve the creamy lemon-garlic sauce on the side of your salmon patties for dipping or topping as you prefer! Garnish with extra parsley and lemon wedges to enhance presentation and flavor before serving.